The Possible Role of Platelet Coagulant Activities in the Pathogenesis of Venous Thrombosis

Peter N Walsh

doi:10.1055/s-0038-1647837

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1975; 33(03): 435-443
DOI: 10.1055/s-0038-1647837

National Conference on Thrombosis and Hemostasis, Dallas, Texas, 20.—22. November 1974

Schattauer GmbH

The Possible Role of Platelet Coagulant Activities in the Pathogenesis of Venous Thrombosis^[*]

Peter N Walsh

¹Specialized Center for Thrombosis Research, Temple University Health Sciences Center, Room 421 – OMS, 3400 North Broad Street, Philadelphia, Pennsylvania 19140

› Author Affiliations

Abstract

Summary

Recent studies of the role of platelets in blood coagulation have shown that platelets can trigger intrinsic coagulation by two alternative pathways, protect platelet-associated active clotting factors from inactivation by plasma inhibitors and catalyze intrinsic coagulation reactions on the platelet surface to form fibrin. These platelet coagulant activities (i.e., contact product forming activity, collagen-induced coagulant activity, intrinsic factor-Xa forming activity and platelet factor 3 activity) were found to be increased in patients with deep vein thrombosis developing after hip surgery, in patients with established retinal vein thrombosis and in patients with established deep vein thrombosis. It is suggested that increases in platelet coagulant activities concerned with triggering and catalyzing intrinsic coagulation reactions may play a role in the pathogenesis of venous thrombosis.

Full Text

References

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The Possible Role of Platelet Coagulant Activities in the Pathogenesis of Venous Thrombosis[*]

The Possible Role of Platelet Coagulant Activities in the Pathogenesis of Venous Thrombosis^[*]